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As adult neurogenesis is negatively correlated with stress and depression (Zhao et al., 2008) and major depression correlates with increased DNA methylation in the cortex (Veldic et al., 2005), this raises an intriguing possibility: could the depression-linked decrease in adult neurogenesis be a consequence of the increased methylation of NeuroD1 promoter in developing neurons

8 Future perspectives The gut microbiota can influence drug bioavailability and efficacy through metabolism, while most psychotropic medications possess anti-inflammatory properties and may directly alter microbial composition

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